硫化可以通过抗衰老途径抑制胎儿膜破裂
Jie Wang1, Jiacheng Xu2, Bingdi Chao2
1The Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Chongqing Key Laboratory of Maternal and Fetal Medicine, Chongqing Medical University, Chongqing, 400016, China; Women and Children's Hospital of Chongqing Medical University, Chongqing, 401147, China.
Placenta
|October 4, 2023
概括
硫化 (H2S) 的含量较低,导致胎儿膜早产破裂 (pPROM),并与胎儿膜衰老的增加有关. H2S捐助者减少衰老和MMPs,保持膜完整性.
科学领域:
- 产科和妇科 产科和妇科
- 生物化学 生物化学
- 细胞生物学 细胞生物学
背景情况:
- 胎儿膜的完整性对于怀孕至关重要.
- 膜早期破裂 (PROM) 是早产的主要原因之一.
- 硫化 (H2S) 在胎儿膜衰老和完整性中的作用尚不清楚.
研究的目的:
- 研究H2S水平与胎儿膜衰老之间的关系.
- 阐明H2S影响胎儿膜完整性的机制.
主要方法:
- 从早产 (PT) 和早产早产破裂膜 (pPROM) 组的胎儿膜中量化H2S和衰老水平.
- 对H2S合成酶 (CBS,CSE) 的评估表达.
- 检查了H2S捐赠者和CBS敲击对羊上皮细胞衰老,矩阵金属蛋白酶 (MMPs) 和上皮-介质细胞过渡 (EMT) 的影响.
主要成果:
- 与PT组相比,pPROM组的H2S水平明显低于PT组.
- H2S水平与胎儿膜衰老有负相关性.
- H2S捐赠者减少了细胞衰老和MMPs的表达.
- 通过CBS的敲击加速衰老,增加MMP和EMT,而L-氨酸的效果被L-氨酸逆转.
结论:
- H2S对胎儿膜衰老起着保护作用.
- H2S影响MMP和EMT,有助于维持胎儿膜完整性.
- H2S可能是预防PROM的治疗目标.
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