化疗或放射治疗期间运动对免疫标记物的影响:系统性审查
Anne M S de Hoop1,2,3, Karin Valkenet1,2, Jaap J Dronkers2
1Department of Rehabilitation, Physiotherapy Science & Sport, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Oncology
|October 4, 2023
概括
在癌症治疗期间定期炼显示出有希望的结果,积极影响免疫标志物,没有负面影响. 进一步的研究将澄清癌症患者的最佳运动策略.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 运动科学 运动科学
背景情况:
- 接受放射或化疗的癌症患者经历免疫应激.
- 慢性定期炼对免疫系统有好处,但过重可能是有害的.
- 目前针对癌症患者的运动建议缺乏有关治疗期间免疫标记物效应的详细证据.
研究的目的:
- 系统地审查中度和高强度运动对癌症患者在化疗或放射治疗期间免疫标记物的影响.
主要方法:
- 在PubMed和EMBASE的系统文献搜索到2023年3月.
- 使用PEDro工具对方法质量的评估.
- 针对每个免疫标记物和炎症概况进行的最佳证据综合.
主要成果:
- 包含了15项方法质量相当或良好的研究.
- 在放射治疗期间的运动对一些促炎性标志物有抑制作用.
- 化疗期间的运动保存了自然杀手 (NK) 细胞降粒和细胞毒性,保护了血小板细胞减少,并积极影响了免疫球蛋白A (IgA).
结论:
- 运动干预措施对癌症患者的特定免疫标志物产生了有希望的,通常是积极的影响.
- 运动没有对免疫标志物产生负面影响,并可能通过抑制炎症提供临床益处.
- 未来的研究应该建立对关键运动反应免疫标记的共识,并调查训练类型和强度的差异性影响.
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