在基于便免疫化学测试的查计划中,经过阴性结肠镜检查后,结肠直肠癌的间隔后结肠镜检查
Hilliene J van de Schootbrugge-Vandermeer1, Arthur I Kooyker1, Pieter H A Wisse2
1Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Endoscopy
|October 4, 2023
概括
在便免疫化学测试 (FIT) 结果呈阳性后,结肠镜检测结果为阴性的人最初患结肠直肠癌 (CRC) 的风险较低. 然而,这种风险在2.5年后与FIT阴性个体的风险相等,这表明查需要改进.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 荷兰结肠直肠癌 (CRC) 查计划使用便免疫化学测试 (FIT),然后进行结肠镜检查以获得阳性结果.
- 阴性结肠镜检查的个体通常在10年后被再次邀请进行查.
研究的目的:
- 为了评估隔间结肠直肠癌 (CRC) 的风险,在FIT结果阳性后进行了阴性结肠镜检查的个体.
主要方法:
- 一项横截面队列研究分析了来自荷兰国家查信息系统 (2014-2018) 的数据.
- 被纳入的参与者有一个积极的FIT,其次是负的结肠镜检查,根据特定的多/腺瘤标准来定义.
- 评估了间歇性结肠镜后CRC (iPCCRC) 风险,并与两个年查间隔的负面FIT后的间歇性CRC风险进行比较.
主要成果:
- 在35,052名阴性结肠镜检查的参与者中,诊断出24例iPCCRC病例.
- 在平均1.4年的随访后,iPCCRC风险为每10,000人中的6.85.
- 在2.5年后,年龄调整后的IPCCRC风险接近2年后在FIT阴性个体中观察到的间隔CRC风险.
结论:
- 在结肠镜检查后的最初几年,iPCCRC的风险较低,但在2.5年后增加,以匹配FIT阴性查水平.
- 调查结果表明,有可能需要提高结肠镜检查质量,并可能减少之前负面结肠镜检查患者的FIT查间隔.
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