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设计,合成针对瘤微环境中的β-葡萄糖酶的auristatins-glucuronide联合体

Yujie Wang1, Keshi Xu2, Hongchun Liu3

  • 1School of Pharmacy, Fudan University, Shanghai 201203, China.

Bioorganic & medicinal chemistry letters
|October 4, 2023
PubMed
概括

新的auristatin-glucuronide结合剂在瘤中准β-glucuronidase. 结合物20和21显示稳定性和强烈的抗癌活性,结合物20在没有副作用的小鼠模型中显示有效性.

关键词:
防止核武器的扩散.欧里斯酸E 欧里斯酸E瘤微环境是一个微环境.这是一种β-Glucuronidase.

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