用于生物医学应用的基于凝的水凝系统的进展:一篇最先进的综述
Sourav Mohanto1, Soumya Narayana1, Khushboo Paresh Merai2
1Department of Pharmaceutics, Yenepoya Pharmacy College & Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, Karnataka, India.
International journal of biological macromolecules
|October 4, 2023
概括
基于凝的水凝为控制药物输送提供了刺激反应,生物相容的平台. 这些先进的生物材料在生物医学和组织工程应用中表现有前途,因为它们具有可调节的特性和自我愈合能力.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 生物医学工程 生物医学工程
背景情况:
- 基于凝的水凝是刺激反应,生物相容性和可生物降解的聚合物系统.
- 它们的多孔网络纠着水分,形成一个层次的交联结构.
- 原体的水解指导着凝的构建,并结合了特定的降解点.
研究的目的:
- 审查以凝为基础的水凝作为生物医学应用的多功能生物材料.
- 讨论凝的来源,结构特征和水凝的发展.
- 探索治疗分子输送方法和相关挑战.
主要方法:
- 对基于凝的水凝现有文献的审查.
- 分析结构性质及其对水凝形成的影响.
- 检查刺激介导的水凝特性,包括剪切稀释和自我恢复.
主要成果:
- 凝水凝可以封装和调节治疗有效载荷的释放,如蛋白质,和药物.
- 功能可调节的生物聚合物增强水凝的多孔性和机械强度,以提高承载能力.
- 具有特定成分的刺激介导水凝具有生物医学用途的理想质性质.
结论:
- 基于凝的水凝是各种生物医学应用的有希望的生物材料,特别是在药物输送中.
- 了解凝来源和结构特征对于优化水凝设计至关重要.
- 需要进一步的研究,以克服治疗交付系统的现有挑战.
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