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使用大鼠模型对大米中的的相对生物可用性及其对人类健康风险评估的应用

Yan Qin¹, Caicheng Huang¹, Guirong Huang¹

¹State Key Laboratory for Conservation and Utilization of Subtropical Agri-bioresources, Guangxi Key Laboratory for Agro-Environment and Agro-Products Safety, College of Agriculture, Guangxi University, Nanning, 530004, China.

Environmental pollution (Barking, Essex : 1987)

|October 4, 2023

概括

富含的米可以防止缺陷,但存在风险. 这项研究测量了大鼠的生物可用性,发现它有所不同,并且取决于甲含量,这表明目前的健康风险评估可能高估了摄入量.

科学领域:

营养科学营养科学
环境健康环境健康
食品化学食品化学

背景情况:

(Se) 是对人类健康至关重要的微量营养素.
缩是一种解决缺乏症的策略,但存在潜在的过度消费风险.
准确评估Se的健康风险需要了解来自大米的Se生物利用性.

研究的目的:

系统地探索来自丰富大米的 (Se-RBA) 的相对生物可用性.
为了评估与Se丰富米的消费相关的人类健康风险,使用鼠体内模型.
为了研究Se分数 (氨酸) 和Se-RBA之间的关系.

主要方法:

开发了一种老鼠体内模型来确定Se-RBA.
分析了来自中国21个省份的196个大米样本中的Se度和物种化 (甲的主导地位).
根据确定的Se-RBA计算的Se摄入量.

主要成果:

米中的Se度在0.06至0.15毫克/公斤之间,其中氨酸是主要的形式 (58.0-96.5%).
来自缩大米的Se-RBA差异很大 (34.86%至102.29%),平均为62.27%.
Se-RBA与大米中氨酸氨酸的比例呈正相关性 (p < 0.05).

结论:

来自含丰富的的计算Se摄入量低于可容忍的上限摄入量水平.
目前的法律限制可能会高估米中Se的营养价值.
考虑到Se的生物可用性对于准确评估来自大米的Se摄入的健康风险至关重要.

关键词:

生物可用性生物可用性危害健康的风险健康风险大米大米大米大米大米是一种.种类的类物种.

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