相关实验视频
Updated: Jul 30, 2026
07:48
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
12.5K
在非转移性肌肉侵入性膀癌中的顺序与并发化疗疗方案的比较
Heidi M Vieira1, David P Kasper1, Runqiu Wang2
1Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA.
Radiation oncology journal
|October 4, 2023
概括
膀癌放射治疗前的顺序化疗显示出与同时治疗相似的生存结果. 这表明化疗可能有助于在放射治疗之前降低瘤的发展阶段,即使是在疾病更晚的患者中也是如此.
科学领域:
- 在瘤学瘤学.
- 尿道瘤学 尿道瘤学
背景情况:
- 肌肉侵入性膀癌往往需要激进囊切除术,这是一种具有显著发病率和死亡率的程序.
- 三种疗法 (化疗辐射后透尿管切除) 提供了节约膀的替代方案,但最佳化疗和辐射测序尚不清楚.
研究的目的:
- 为了比较顺序与并发化疗在非转移性肌肉侵入性膀癌的生存结果.
- 评估化疗时间相对于辐射对患者存活时间的影响.
主要方法:
- 来自国家癌症数据库的2227名非转移性膀癌患者的回顾性分析.
- 顺序化疗 (在放射治疗前14天开始) 和并发化疗 (在放射治疗后14天内开始) 之间的整体存活率的比较.
主要成果:
- 顺序组更年轻,病情更为晚期.
- 在顺序和并发化学辐射组之间没有观察到总生存时间的显著差异 (p=0.533).
结论:
- 放射前的化疗与同时的化疗相比,不会对存活率产生负面影响.
- 顺序化疗可能对膀癌患者的下降瘤有益,需要进一步调查.
- 需要进一步的多机构试验来指导临床决策,以确定治疗顺序.
更多相关视频
相关概念视频
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.