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对肺部类癌的激进放射治疗的临床结果

Choong-Won Lee¹, Byoung Hyuck Kim^2,3, Hak Jae Kim^1,3

¹Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea.

Radiation oncology journal

|October 4, 2023

概括

肺肉类瘤 (PSC) 的激进放射治疗在一些患者中显示出治愈的潜力. 瘤大小和辐射剂量是影响这种侵袭性肺癌结果的关键因素.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
肺部医学肺部医学

背景情况:

肺肉类瘤 (PSC) 是一种具有不良预后的侵袭性肺癌.
由于有限的数据,PSC激进放射治疗的疗效尚未得到充分确立.

研究的目的:

评估治疗结果,并确定PSC中激进放射治疗的预后因素.
为了探索治疗这种罕见的肺癌的治疗潜力.
在没有有效的全身性药物的情况下,研究激进放射治疗的作用.

主要方法:

从2005年1月至2021年12月,对149名PSC患者的回顾性分析.
专注于62名接受肺病变放射治疗的患者,不包括息病例和手术.
收集有关患者人口统计,瘤特征,治疗细节和结果的数据.

主要成果:

平均年龄为71岁,81%的患者被诊断为晚期患者.
激进放射治疗导致局部复发率低 (9.5%),但远程转移率为47.6%.
五名患者 (26.3%) 实现了部分或完全缓解;中位数PFS为4.6个月,OS为7.9个月.
瘤大小>5厘米与更差的预后相关;辐射剂量>58 GyEQD2与更好的PFS相关.

结论:

激进的放射治疗可以在选择的PSC患者中实现完全缓解.
瘤大小和辐射剂量是系统性反应的潜在预测因素.
需要进一步的研究来优化PSC的激进放射治疗策略.

关键词:

肺部的新生病是肺部的新生病.辐射疗法辐射疗法这种类型的肉瘤是sarcoma.

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