可能的梦症和死亡率:美国男性前性研究
Xinyuan Zhang1, Samantha A Molsberry2, Milena Pavlova3
1Department of Nutritional Sciences, Pennsylvania State University, University Park, MA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Mayo Clinic proceedings
|October 4, 2023
概括
像快速眼动睡眠行为障碍 (RBD) 和睡眠行走 (SW) 这样的偏眼症与增加的死亡风险有关. 这包括因各种原因死亡,神经退行性疾病和事故的风险更高.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 偏睡症,包括快速眼动睡眠行为障碍 (RBD) 和睡眠行走 (SW),是睡眠期间兴奋的障碍.
- 在大群体中,这些病症和长期死亡风险之间的关联仍然不完全理解.
研究的目的:
- 调查可能的睡症 (pRBD和pSW) 与所有原因和特定原因死亡率之间的关系.
- 评估与pRBD和pSW的同时发生和单独存在相关的死亡风险.
主要方法:
- 一项针对美国25695名男性卫生专业人员的前性队列研究 (卫生专业人员随访研究).
- 可能的SW (pSW) 和可能的RBD (pRBD) 在2012年使用梅奥睡眠问卷进行了评估.
- 从2012年到2018年,通过国家登记册和其他来源收集了死亡率数据 (全因和因特定).
主要成果:
- 在6年的随访期间,记录了4743例死亡.
- 同时出现pSW和pRBD与全因死亡风险增加1.65倍有关.
- 这两种病症结合起来,显著增加了神经退行性疾病 (HR 4.57) 和事故 (HR 7.36) 的死亡风险.
- 个体pSW与全因死亡率有关,而pSW和pRBD都与因神经退行性疾病和意外死亡风险增加有关.
结论:
- 可能的睡眠障碍与所有原因死亡率的风险增加有关.
- 这些睡眠障碍与神经退行性疾病和意外死亡率的增加密切相关.
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