使用[18F]DK222-PET成像在癌症免疫治疗中的非侵入性PD-L1量化
Akhilesh Mishra1,2, Kuldeep Gupta1, Dhiraj Kumar1
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA.
Journal for immunotherapy of cancer
|October 4, 2023
概括
这项研究表明[18F]DK222-PET可以在癌症免疫疗法中非侵入性地监测编程死亡配体1 (PD-L1) 表达和治疗效果. 该成像剂在人性化小鼠模型中成功检测出治疗诱导的变化和差异化治疗影响.
科学领域:
- 分子成像和癌症治疗方法
- 免疫学和瘤学研究研究
背景情况:
- 组合免疫疗法需要非侵入性生物标志物来评估临床疗效.
- 编程死亡连接体1 (PD-L1) 是癌症免疫治疗中的一个关键目标.
- 定子发射断层扫描 (PET) 为监测治疗点提供了一种非侵入性方法.
研究的目的:
- 调查[18F]DK222,一种基于的新型标记物,用于成像PD-L1表达.
- 用PET评估PD-L1表达和治疗诱导的癌症变化之间的关系.
- 评估[18F]DK222-PET在监测免疫治疗反应和瘤异质性的有用性.
主要方法:
- 在非小细胞肺癌 (NSCLC) 和尿路细胞癌 (UC) 中对PD-L1进行验证的[18F]DK222特异性.
- 使用PET量化PD-L1变化诱导的抗编程细胞死亡蛋白-1 (PD-1) 治疗在人性化小鼠.
- 在黑色素瘤模型中,在单疗法和组合免疫疗法期间,评估了PD-L1药理动力学与[18F]DK222-PET.
主要成果:
- [18F]DK222-PET在NSCLC和UC模型中证明了与PD-L1表达相关的可变瘤吸收.
- 在抗PD-1治疗后的微卫星不稳定性 (MSI) 瘤和联合治疗与单一治疗中观察到[18F]DK222摄取量的增加.
- 与单一治疗相比,组合疗法显示了更高的PD-L1表达,增加了CD8+/CD4+T细胞比率,以及明显的空间免疫透模式.
结论:
- [18F]DK222-PET作为一种有希望的非侵入性工具,用于监测免疫治疗对PD-L1表达的影响.
- 该药物可以检测疗法诱导的变化,并区分各种免疫疗法方案的影响.
- PET成像提供了对病理和免疫学变化的洞察力,有助于治疗评估.
更多相关视频
06:51Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
18.0K
09:06Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
Published on: February 3, 2023
1.5K
相关概念视频
01:29Positron Emission Tomography
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET