血红蛋白和费里丁的儿科参考间隔和曲线:系统审查和元分析的协议
Vid Bijelić1, Beth Potter2, Patricia C Parkin3
1School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada vbije016@uottawa.ca.
BMJ open
|October 4, 2023
概括
本综述综合了关于儿科费里和血红蛋白参考间隔的证据. 它旨在量化异质性,并确定其估计方法的变化来源.
科学领域:
- 儿科实验室医学 儿科实验室医学
- 临床生物化学 临床生物化学
- 证据综合 证据综合
背景情况:
- 参考间隔对于解释儿科实验室测试结果至关重要.
- 已经确立的指导方针存在,用于创建参考间隔,并为儿童提供全球倡议.
- 缺乏关于铁生物标志物,特别是铁和血红蛋白的儿科参考间隔的综合证据.
研究的目的:
- 确定为儿科费里和血红蛋白提供参考间隔和曲线的研究.
- 综合这些儿科参考间隔的现有证据.
- 量化异质性,并确定其估计变化的来源.
主要方法:
- 通过EMBASE,MEDLINE,SCOPUS和科克兰图书馆进行全面的文献搜索.
- 包括健康群体未发表的参考间隔的灰色文献.
- 两个研究人员对研究进行独立选,随后进行数据提取和叙述和定量综合.
主要成果:
- 符合条件的研究将为儿科患者群体的血清/血费里丁和血红蛋白提供参考间隔和曲线.
- 提取的数据将包括研究特征,参考人口细节和方法考虑.
- 估计的参考间隔和曲线上的异质性将被量化和分析.
结论:
- 这一系统性审查将提供有关费里和血红蛋白的儿科参考间隔的全面综合.
- 了解异质性将有助于标准化这些重要生物标志物的估计.
- 结果将为临床实践和未来儿童铁状况评估研究提供信息.
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