视力保护疗法用于预防新血管与年龄相关的黄斑变性
Jeffrey K Luttrull1,2, Gerry Gray3, Sathy V Bhavan4
1Ventura County Retina Vitreous Medical Group, Ventura, CA, USA. jkluttrull@proton.me.
Scientific reports
|October 4, 2023
概括
与标准护理相比,视力保护疗法 (VPT) 在与年龄相关的黄斑变性 (AMD) 中显著降低了新血管转化. 这种疗法还可以改善视力敏度,特别是在高风险患者中.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 视觉科学 视觉科学 视觉科学
背景情况:
- 与年龄相关的黄斑变性 (AMD) 是全球不可逆转的视力丧失的主要原因.
- 神经血管 (湿) AMD代表了疾病的晚期,视力威胁的阶段.
- 目前对干性AMD的标准护理可能不足以防止进展到湿性AMD.
研究的目的:
- 评估视力保护疗法 (VPT) 在预防与年龄相关的黄斑退行症 (AMD) 患者的神经血管转化方面的疗效.
- 为了比较使用VPT治疗的眼睛和仅接受标准护理 (SCA) 的眼睛之间从干燥到湿湿的AMD转换率.
- 评估VPT对AMD患者视力敏度的影响.
主要方法:
- 从320多名美国视网膜专家 (2017年1月至2023年7月) 获得的非识别患者数据的回顾性分析.
- 倾向性得分匹配被用来比较737个VPT治疗眼睛和7370个SCA治疗眼睛,考虑神经血管转化风险因素.
- 进行了子组分析,包括对遭遇频率进行匹配,并将SCA与VPT治疗的眼睛进行比较.
主要成果:
- 与SCA相比,VPT显著降低了神经血管转换的风险 (HR 5.73,p < 0.0001),即使调整了遭遇频率.
- 在整个研究期间,VPT治疗的眼睛始终表现出更好的视力敏度.
- 在转换风险因素较高的眼睛中,VPT的益处更为明显,例如年龄较大和更严重的干燥 AMD.
结论:
- 视力保护疗法在预防新血管AMD方面明显比标准护理更有效.
- VPT不仅降低了转化率,而且还改善了AMD患者的视力敏度.
- 该疗法提供了显著的益处,特别是对于干燥的AMD患者,他们面临着进展到湿形的高风险.
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