对抗血活性试验的比较,用于检测肝素结合部位抗血缺乏症患者:系统综述和元分析
Tamara Rojnik1,2, Nataša Sedlar3, Nana Turk4
1Laboratory for Haemostasis and Atherothrombosis, Department of Vascular Diseases, University Medical Centre Ljubljana, 1000, Ljubljana, Slovenia. tamara.rojnik@kclj.si.
Scientific reports
|October 4, 2023
概括
抗血素 (AT) 缺陷测定在检测AT Budapest III和AT Padua I等突变时的灵敏度不同.Innovance,Labexpert和Sta-Stachrom显示出更高的灵敏度,而HemosIL对这些特定的AT缺陷敏感度较低.
科学领域:
- 生物化学 生物化学
- 血液学 血液学 血液学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 抗血素 (AT) 缺乏是静脉血栓栓塞的重要危险因素.
- 通过敏感测试准确识别AT缺乏症对于患者管理至关重要.
- 肝素结合部位AT缺陷,如AT Budapest III和AT Padua I,需要特别的诊断考虑.
结论:
- 针对II型肝素结合部位AT缺陷的AT活性试验的诊断灵敏度取决于试验和突变特异性.
- 建议使用Innovance,Labexpert和Sta-Stachrom作为检测AT Budapest III和AT Padua I的敏感试验.
- 在患有这些特定的AT缺乏变异的患者中,HemosIL可能不太适合准确量化AT活性.
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