运动对抗癌症免疫力的影响
Carmen Fiuza-Luces1, Pedro L Valenzuela2,3, Beatriz G Gálvez2,4
1Physical Activity and Health Research Group ('PaHerg'), Research Institute of the Hospital 12 de Octubre ('imas12'), Madrid, Spain. cfiuza.imas12@h12o.es.
Nature reviews. Immunology
|October 4, 2023
概括
定期炼可以增强免疫系统,提高免疫系统对抗癌症的能力. 本综述探讨了急性和定期的身体活动如何影响抗癌免疫力和潜在的治疗应用.
科学领域:
- 运动免疫学 运动免疫学
- 癌症生物学 癌症生物学
- 免疫治疗是一种免疫疗法.
背景情况:
- 身体活动与减少癌症发病率,死亡率和复发率有关.
- 动物模型显示,运动会延迟癌症的进展,即使是攻击性类型.
- 机制包括加强癌症免疫监测和免疫细胞透到瘤中.
研究的目的:
- 审查急性和定期运动对抗癌免疫力的影响.
- 讨论通过运动刺激的免疫细胞亚型的作用.
- 探索潜在的临床应用,包括采用细胞疗法.
主要方法:
- 对流行病学和临床前研究的审查.
- 分析免疫细胞对急性和定期运动的反应.
- 讨论运动抗瘤原源作用的拟议机制.
主要成果:
- 运动刺激免疫细胞透瘤,增强免疫监测.
- 单次发作 (急性) 和持续训练 (定期) 都会影响抗癌免疫力.
- 运动后的免疫细胞显示出采用细胞治疗的潜力.
结论:
- 肌肉活动对于免疫系统健康和癌症预防至关重要.
- 运动通过各种机制调节对癌症的免疫反应.
- 新兴研究强调了运动对癌症治疗和预防的临床影响.
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