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在抗PD-1和联合免疫检查点抑制中,特定于毒性的外周血液T和B细胞动态

Mick J M van Eijs1,2, Rik J Verheijden3, Stefanie A van der Wees4

  • 1Department of Medical Oncology, University Medical Center Utrecht, KC.02.085.2, P.O. Box 85090, 3508 AB, Utrecht, the Netherlands. m.j.m.vaneijs-2@umcutrecht.nl.

Cancer immunology, immunotherapy : CII
|October 4, 2023
PubMed
概括

免疫检查点抑制剂 (ICI) 毒性涉及提升的Th1反应,联合ICI也显示Th17激活和生殖中心变化. 这些发现支持基于ICI治疗方案的针对免疫相关不良事件 (irAEs) 量身定制的治疗方法.

关键词:
免疫检查点抑制剂 免疫检查点抑制剂与免疫相关的不良事件.周围血液,免疫类型的形成.在T和B淋巴细胞.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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