在健康和疾病中,Resolvins和Efferocytosis之间的接口
Fatemeh Mohammad-Rafiei1, Samira Negahdari2, Zahra Tahershamsi3
1Department of Medical Biotechnology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Cell biochemistry and biophysics
|October 4, 2023
概括
从omega-3脂肪酸中提取的溶解素 (RvD和RvE) 通过增强血细胞分裂 (efferocytosis),即亡细胞的清除来促进炎症的解决. 了解这种联系为炎症性疾病提供了新的治疗策略.
科学领域:
- 生物医学科学 生物医学科学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 急性炎症的解决对于组织平衡和宿主防御至关重要.
- 来自omega-3脂肪酸的溶解素 (RvD,RvE) 是具有抗炎和促溶解功能的关键调解剂.
- 巨介导的细胞衰变 (细胞清除) 对于解决炎症至关重要.
研究的目的:
- 审查和综合当前关于溶解素和在炎症解决过程中效细胞体之间的关系的知识.
- 为了探索背后的分子机制解决因子增强的血细胞分裂.
- 为了确定潜在的治疗点的炎症状况,与受损的血细胞增生或分辨率.
主要方法:
- 对近期研究的文献综述 关于溶解素,乙细胞和炎症解决的研究.
- 分析分子通路,将溶解作用与细胞过程连接起来.
- 从体外和体外实验模型中综合数据.
主要成果:
- 从多可萨赫萨酸中衍生出的Resolvin D1 (RvD1) 已被证明可以增强血细胞分裂.
- 目前正在阐明特定的分子机制,通过这些机制,溶解素调节了细胞分裂.
- 在生理学和病理学上存在强烈的互动在溶解素和乙细胞分裂之间.
结论:
- 溶解素和乙细胞分裂之间的相互作用是有效的炎症解决的关键组成部分.
- 进一步了解这些机制可能会导致针对炎症性疾病的新型治疗干预措施.
- 准溶解素 - 乙细胞分裂轴对治疗缺陷乙细胞分裂的特征有希望.
相关概念视频
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
00:58Recycling Endosomes and Transcytosis
2.7K
The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
2.7K
01:28The Early Endosome: Endocytosis of Transferrin
3.3K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
3.3K
01:39Receptor-mediated Endocytosis
104.6K
Overview
104.6K
01:45ER Retrieval Pathway
3.9K
In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
3.9K
01:29Protein Folding Quality Check in the RER
3.7K
ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
3.7K