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在HeartMate 3植入后发生机械并发症
Aurelie Merlo1, Panagiotis Tasoudis2, Guilherme C de Oliveira2
1Department of Surgery, University of North Carolina at Chapel Hill, 4005 Burnett-Womack, CB #7050, Chapel Hill, NC, 27599-7050, USA. Aurelie.merlo@unchealth.unc.edu.
Journal of thrombosis and thrombolysis
|October 4, 2023
概括
机械并发症发生在接受HeartMate 3左心室辅助装置 (LVAD) 的7.8%的患者中,往往晚发. 这凸显了需要解决长期并发症以改善LVAD结果的必要性.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 手术技术 手术技术
背景情况:
- 左心室辅助装置 (LVAD) 植入改善了生存率,但长期并发症需要进一步调查.
- 减少晚期并发症对于优化LVAD患者的临床结果至关重要.
研究的目的:
- 为了确定在HeartMate 3 LVAD植入后需要手术干预的机械故障的发生率.
- 将故障定义为外流移植压缩,阻塞或血栓,需要手术.
主要方法:
- 一项对141名通过"切然后"技术接受HeartMate 3 LVADs的成年患者的回顾性研究 (2015年9月 - 2021年9月).
- 主要终点:需要手术的机械并发症 (外流移植阻塞/血栓).
- 二级终点:出血,中风,功能衰竭,停留时间和生存时间;中位数随访时间:27.3个月.
主要成果:
- 11名患者 (7.8%) 经历了机械并发症:6人患有外流移植阻塞,5人患有血栓.
- 机械并发症的中位时间为828天.
- 在11名接受手术治疗的患者中,10名 (90%) 存活到出院;1,3年和5年的整体存活率分别为82.9%,69.1%和55.2%.
结论:
- 机械并发症率为7.8%,中位数发病时间为828天,表明LVAD植入后出现了显著的晚期并发症.
- 这项研究强调了监测和管理LVAD接收者晚期出现的机械问题的重要性.
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