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生物标志物工具包 - - 一个基于证据的指导方针,用于预测癌症生物标志物的成功,并指导癌症生物标志物的开发

Katerina-Vanessa Savva¹, Michal Kawka², Bhamini Vadhwana²

¹Division of Surgery, Department of Surgery and Cancer, Imperial College London, London, UK. k.savva17@imperial.ac.uk.

|October 4, 2023

概括

一个新的检查清单确定了成功翻译癌症生物标志物的关键属性. 本生物标志物工具包有助于选择有前途的生物标志物用于临床采用,弥合发现到使用的差距.

科学领域:

生物标志物发现和翻译
临床瘤学临床瘤学
翻译研究是翻译研究.

背景情况:

在癌症生物标志物发现方面投入了大量资源,但临床采用仍然很低.
在识别潜在生物标志物和在临床实践中成功实施它们之间存在差距.
需要工具来引导生物标志物开发向临床实用性发展.

研究的目的:

开发和验证一个全面的检查清单,生物标志物工具包,用于识别临床有前途的生物标志物.
促进发现的生物标志物的转化到临床实践中.
改进生物标志物研究的设计和执行.

主要方法:

采用了混合方法的方法,包括系统的文献搜索,专家采访和Delphi调查.
确定和分类了与临床有用生物标志物相关的129个属性.
该检查清单使用乳腺癌和结直肠癌生物标志物进行了验证,评估了它们的临床和非临床实施.

主要成果:

该研究确定了129个属性,分为合理性,临床实用性,分析有效性和临床有效性.
通过Delphi调查,在确定属性方面达成了高专家一致意见 (88.23%).
基于检查清单的综合评分显著预测了乳腺癌和结直肠癌中的生物标志物成功率 (p<0.0001).

结论:

已经生成了一个有效的属性清单,用于成功实现生物标志物的属性.
生物标志物工具包可以识别具有高临床潜力的生物标志物.
该工具可以指导未来生物标志物研究的设计和执行,以提高临床翻译.

关键词:

生物标志物生物标志物乳腺癌乳腺癌乳腺癌临床实用性的临床实用性结肠直肠癌是一种癌症.翻译研究是翻译研究.

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