雄激素过量和不足:分析和诊断方法
Annemieke C Heijboer1,2,3,4, Sabine E Hannema2,4,5
1Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.
Clinical chemistry
|October 5, 2023
概括
精确的雄激素测量对于诊断激素失衡,如过量或缺乏,至关重要. 本综述详细介绍了诊断方法,并强调了测试技术和预分析因素对可靠结果的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 临床化学 临床化学
背景情况:
- 雄激素是从胆固醇中合成的重要激素,在一生中调节发育和成熟.
- 雄激素水平 (过量或不足) 的不平衡在不同的生命阶段表现得不同.
研究的目的:
- 审查与雄激素失衡相关的疾病的诊断方法.
- 讨论测量各种雄激素的方法和挑战.
- 突出分析前和分析因素在解释雄激素水平的重要性.
主要方法:
- 对非典型生殖器,青春期障碍和高雄性质症的诊断策略的审查.
- 讨论雄激素测量技术,包括免疫测试和液体染色体质谱法 (LC-MS).
- 考虑样品类型 (血清,唾液,尿液,干血斑) 和分析前的变量.
主要成果:
- 雄激素水平在一生中波动,对发育至关重要.
- 不同的诊断条件需要对雄激素进行测量,包括丸激素,androstenedione和dehydroepiandrosterone.
- 免疫试验和LC-MS具有明显的优势和局限性;分析前因素对结果产生重大影响.
结论:
- 准确的雄激素水平评估对于诊断和管理与雄激素过量或不足相关的疾病至关重要.
- 未来的进展可能会引入新的雄激素测定,以提高诊断精度和患者随访.
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