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在精神病患者服用抗精神病药物治疗肥胖症时使用芬特明
Eunju Kim1,2, Daniel Rim1, Jeong-Hun Shin1,3
1Section of Endocrinology, Diabetes and Weight Management, Boston University, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Psychiatry investigation
|October 5, 2023
概括
芬特明在服用抗精神病药物的肥胖患者中有效降低体重,抗联合治疗 (ACT) 增强了结果. 治疗耐受性良好,表现出常见的副作用,如睡眠障碍和口腔干燥.
科学领域:
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
背景情况:
- 胺是一种常见的减肥药在美国.
- 关于服用抗精神病药物的肥胖患者使用芬特明的数据有限.
研究的目的:
- 评估丁胺在服用抗精神病药物的肥胖患者体重管理中的疗效和耐受性.
- 在这个人群中识别与素反应相关的因素.
主要方法:
- 一项为期6个月的研究,涉及57名肥胖患者接受治疗的抗精神病药物.
- 收集的数据包括人类学变量和不良事件.
- 患者被分为响应者 (BWR% ≥5%) 和不响应者 (BWR% <5%).
主要成果:
- 6个月后,平均体重减轻 (BWR) 为4.45公斤 (3.92%).
- 受访者显示抗联合治疗 (ACT) 的比率更高,抗精神病药物暴露时间更短.
- ACT与芬特明的反应有显著的相关性 (OR=3.840).
结论:
- 芬特明在服用抗精神病药物的肥胖患者的减肥中是有效的,并且可以很好地容忍.
- 抗药联合治疗 (ACT),特别是托皮拉,增强了芬特明的减肥效果.
- 常见的不良事件包括睡眠障碍,口腔干燥和头,没有报告新的精神病症状.
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