血干扰素-马诱导蛋白10水平作为自发性乙型肝炎表面抗原血清清除在慢性乙型肝炎患者的预测因素
Karin Kan1,2, Danny Ka-Ho Wong1,2, Rex Wan-Hin Hui1
1Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong.
Journal of gastroenterology and hepatology
|October 5, 2023
概括
低水平的干扰素-诱导蛋白10 (IP-10) 在血中预测自发性乙型肝炎表面抗原 (HBsAg) 血清清除在慢性乙型肝炎患者. 这一发现为预测功能治愈提供了潜在的生物标志物.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 乙型肝炎表面抗原 (HBsAg) 的自发血清表示慢性乙型肝炎 (CHB) 的功能治愈.
- 确定HBsAg血清清除的预测因子对于管理CHB患者和评估治疗结果至关重要.
研究的目的:
- 为了确定与CHB患者自发HBsAg血清清除相关的宿主和病毒因素.
- 调查细胞因子概况,特别是IP-10在预测HBsAg血清清除中的作用.
主要方法:
- 在玛丽女王医院从100名CHB患者 (2011-2021) 的血样本进行了回顾性分析.
- 细胞因子概况的纵向比较,重点是IP-10水平,在获得HBsAg血清清除的患者和没有达到HBsAg血清清除的患者之间.
主要成果:
- 与对照人群相比,在HBsAg血清清除前3-5年观察到显著较低的血IP-10水平.
- 接收器操作特征 (ROC) 曲线分析表明IP-10水平可以预测血清清除,曲线下的面积 (AUC) > 0.7.7.
- 低IP-10水平 (42.39 pg/mL) 显示出74.0%的灵敏度和75.5%的特异性,用于预测3-5年内血清清除,特别是在具有低定量HBsAg的患者中.
结论:
- 低血IP-10水平与随后的HBsAg血清清除有关.
- 测量IP-10可以作为一个有价值的临床工具来预测HBsAg血清清除,特别是在低HBsAg水平的个体.
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