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Updated: Jul 15, 2025

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

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以乙基组为导向的区域选择性C2基化,通过Pd-Ag双金属催化剂对内进行基化

Aditya Paul1, Arunava Sengupta1, Bijan Sarkar1

  • 1Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM) Dhanbad, Jharkhand 826004, India.

The Journal of organic chemistry
|October 5, 2023
PubMed
概括

这项研究引入了一种新型的3-氧导向组,用于印的区域选择性C2基化. 催化反应通过C-H激活提供了一种新的通过C-H激活的醇功能化的方法.

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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate06:46

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α-Alkylation of Ketones via Enolate Ions

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Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation

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Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
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All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
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