胃酸预防在接受脏移植患者的长期影响
Halil Yazici1, Ozgur Akin Oto1, Safak Mirioglu1,2
1Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
概括
质子抑制剂 (PPI) 和H2受体对抗剂在移植后很常见. 这项研究发现,PPI不会增加急性排斥或移植损失,但可能会导致移植接受者的轻度低磁性血.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 药理学 药理学是指药理学的学科.
- 移植医学 移植医学
背景情况:
- 使用质子抑制剂 (PPI) 或H2受体对抗剂的预防性酸抑制通常在移植后被处方.
- 这些药物对急性排斥,低磁性血和移植存活等关键结果的影响仍然不完全理解.
研究的目的:
- 调查胃酸抑制剂 (PPI和H2RA) 与移植接受者的关键结果之间的关联.
- 评估PPI/H2RA使用与活检证明的急性排斥,移植损失和低磁性血的关系.
主要方法:
- 一项回顾性队列研究包括302名脏移植接受者,随访时间超过6个月.
- 接受者被分为四组:仅使用PPI,仅使用H2RA,组合PPI/H2RA和非使用者.
- 主要结局是急性排斥;次要结局包括移植损失和低磁性血.
主要成果:
- 在四组中,在活检证明的急性排斥率中没有显著差异 (p=0.266).
- 所有组的10年移植存活率都相似,没有统计学上显著的变化 (p=0.275).
- 虽然与排斥或移植损失无关,但使用质子抑制剂与轻度低磁性血症有关.
结论:
- 在移植接受者中使用质子抑制剂与急性排斥或移植损失的风险增加无关.
- 这些发现表明,PPI可能会导致轻度低血症,因此需要考虑监测水平.
- 用PPI或H2RA抑制胃酸似乎不会对这一队列的长期移植存活产生负面影响.
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