体重不足和超重对肺结核患者死亡率的影响
Jinsoo Min1, Ju Sang Kim2, Hyung Woo Kim2
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
营养不良显著影响结核病 (TB) 的结果. 体重不足会增加死亡风险,而超重会提供一些保护,在结核病患者中观察到性别特异性差异.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 营养科学 营养科学
背景情况:
- 营养不良是肺结核 (TB) 患者疾病严重程度和死亡率增加的已知危险因素.
- 关于体重不足和超重条件对结核病结果的具体影响,特别是关于基于性别的差异的理解有限.
研究的目的:
- 研究肺结核诊断患者的体重指数 (BMI) 和死亡率之间的关联.
- 探索体重不足和超重状态对结核病相关和非结核病相关死亡率的性别特异性影响.
主要方法:
- 利用了全国性结核病注册数据库,其中包括9,721名肺结核病患者.
- 使用后勤回归分析来评估BMI对死亡率的持续和分类 (体重不足,正常,超重) 影响.
- 进行了按性别分层的子组分析,以确定差异效应.
主要成果:
- 在BMI和死亡率之间观察到显著的反向关系 (aOR = 0.893).
- 体重不足患者的死亡率显著增加 (aOR=2.057),特别是结核病相关的死亡.
- 超重状态表明,对女性的结核病相关死亡 (aOR = 0.500) 和男性的非结核病相关死亡 (aOR = 0.739) 有保护作用.
结论:
- 体重不足状态是肺结核患者死亡率增加的关键预测因素.
- 超重状态可能会赋予生存优势,性别特异性模式会影响死亡风险和死亡原因.
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