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创伤性脑损伤相关的表观遗传变化和神经退行性疾病的风险

Paul Smolen¹, Pramod K Dash¹, John B Redell¹

¹Department of Neurobiology and Anatomy, McGovern Medical School, University of Texas Health Science Center, Houston, TX, United States.

Frontiers in neuroscience

|October 5, 2023

概括

创伤性脑损伤 (TBI) 可以导致持久的表观遗传变化,这可能会增加神经退行性疾病 (ND) 的风险. 研究探讨了这些持续变化如何导致阿尔茨海默氏症和帕金森病等疾病.

科学领域:

神经科学是一个神经科学.
遗传学遗传学是一个
病理学病理学病理学

背景情况:

流行病学研究将创伤性脑损伤 (TBI) 与神经退行性疾病 (NDs) 的风险增加联系起来.
无论是TBI还是ND都与显著的表观遗传修饰有关.
连接TBI诱导的表观遗传变化与ND发展的分子机制在很大程度上是未知的.

研究的目的:

审查TBI相关的表观遗传变化及其潜在的持续性.
探索TBI后持续的表观遗传修饰与发展NDs的风险之间的联系.
讨论潜在的治疗策略,以预防或延迟TBI后的ND.

主要方法:

对TBI和NDs现有的流行病学和分子研究的审查.
对与TBI相关的表观遗传修饰的分析.
检查持续表观遗传变化的证据及其在神经炎症和ND病变发生中的作用.

主要成果:

创伤诱导广泛的表观遗传修饰,可以持续长期.
持续的TBI相关的表观遗传变化可能会导致神经炎症等病理过程.
这些持续的变化被假设为促进特定的NDs的发展,包括阿尔茨海默病,帕金森病和慢性创伤性脑病变.

结论:

创伤后持续的表观遗传变化是将脑损伤与神经退行联系起来的潜在机制.
了解这些分子通路可能会揭示新的治疗点.
旨在减轻持续表观遗传变化的干预措施可以帮助预防或延迟TBI后ND的发展.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.帕金森病是帕金森氏症的一种疾病.通过乙化处理.痴呆症痴呆症是一种痴呆症.脑病变 - 脑病变是一种脑病变.表观遗传学是指表观遗传学.这是一个反循环.甲基化处理甲基化处理

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