加巴丁作为新生儿阿片类药物戒断综合征的辅助疗法:一个案例系列
Caroline Patz1, Caren Liviskie1, Merielle Bird2,3
1Department of Pharmacy (CP, CL, BZ, CM), St. Louis Children's Hospital, St. Louis, MO.
概括
gabapentin 在新生儿阿片类药物戒断综合征 (NOWS) 的婴儿中帮助了吗啡断奶,这些婴儿以前未能接受治疗. 这种辅助疗法在一小群患者中促进了成功停止吗啡治疗.
科学领域:
- 新生儿科学 新生儿科学
- 药理学 药理学是指药理学的学科.
- 儿科重症监护 儿科重症监护
背景情况:
- 新生儿阿片类药物戒断综合征 (NOWS) 提出了重大的临床挑战.
- 目前的治疗方案往往涉及吗啡,但有些婴儿在断奶过程中扎.
- 正在探索辅助疗法,以改善NOWS的治疗结果.
研究的目的:
- 评估 gabapentin 作为诊断为NOWS 的婴儿辅助治疗的疗效.
- 评估 gabapentin 在难以治疗的 NOWS 病例中促进吗啡断奶中的作用.
主要方法:
- 对于NOWS治疗 gabapentin 的婴儿的回顾性图表审查.
- 数据收集包括患者人口统计,母亲的阿片类药物暴露和治疗细节.
- 分析的重点是吗啡断奶的成功,持续时间和 gabapentin 剂量.
主要成果:
- 六名患有NOWS的婴儿接受了 gabapentin 作为辅助治疗.
- 所有的婴儿以前都曾经多次失败了吗啡断奶尝试,即使是克洛尼丁.
- gabapentin 促进了所有六个婴儿成功的吗啡断奶,断奶时间从4-35天不等.
结论:
- gabapentin 证明了作为NOWS有效辅助治疗的潜力.
- 它似乎有助于在对标准护理不耐药的婴儿中成功断奶吗啡.
- 需要进一步的研究,以在更大的队列中证实这些发现.
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