暴露于热应激会导致肠道微生物群,转录组和肉的代谢组发生变化
Xuan Liu1, Zhenhua Ma1, Yanfei Wang1
1Shanxi Key Lab. for the Modernization of TCVM, College of Life and Science, Shanxi Agricultural University, Taigu, China.
Frontiers in microbiology
|October 5, 2023
概括
热应激通过改变基因表达,新陈代谢和肠道微生物群,对肉生长产生负面影响. 了解这些复杂的相互作用是减轻家禽生产损失的关键.
科学领域:
- 禽畜科学 禽畜科学 禽畜科学
- 动物生理学 动物生理学
- 微生物学 微生物学
背景情况:
- 热应激对家禽生产构成重大挑战,通过复杂的生物机制影响生长和健康.
- 在肉热应激下,遗传,代谢和微生物因素之间的复杂相互作用仍然不完全理解.
研究的目的:
- 为了研究热应激对Arbor Acres肉的多种影响.
- 阐明热应激引起的遗传,代谢和微生物变化之间的复杂相互作用.
- 确定受热应激影响的关键途径和分子相关性.
主要方法:
- 肉从28天到42天的年龄被 subjected to controlled heat stress conditions (31°C每天8小时) 从28天到42天的年龄受到受控的热应激条件.
- 进行了结组织和内容的生长性能,转录组,代谢组和代谢组分析.
- 采用多主题数据整合和相关性分析来确定相互连接的生物途径.
主要成果:
- 热应激显著减少肉的平均每日增长和体重 (p < 0.05).
- 不同基因表达在NF-κB信号通路中得到丰富,而代谢物在mTOR信号通路中得到丰富.
- 热应激改变了微生物的组成,增加了蛋白质细菌和减少了菌;纯素代谢是跨欧米水平的关键共同参与途径.
结论:
- 热应激会诱导氧化应激,促进有害细菌,并损害肉的营养吸收和抗氧化能力.
- 这些影响总的来说会损害肠道健康和免疫功能,导致生长性能下降.
- 这些发现为通过复杂的监管见解解决家禽生产中热应激挑战提供了理论基础.
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