对多种维生素的同时暴露以及糖尿病患者因任何原因死亡的风险

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Lin Zhou¹, Jianing Zhang¹, Dan Zhang²

¹School of Public Health, Shenyang Medical College, Shenyang, China.

Frontiers in endocrinology

|October 5, 2023

概括

高水平的多种维生素联合暴露显著降低了糖尿病患者因任何原因死亡的风险. 这一发现凸显了考虑结合维生素摄入量和糖尿病护理中的特定人群变异的重要性.

科学领域:

营养流行病学营养流行病学
代谢疾病代谢疾病
公共卫生公共卫生

背景情况:

已知单个维生素对糖尿病死亡率的影响,但对组合维生素暴露的了解较少.
同时接触多种维生素在日常生活中很常见,需要研究它们的协同作用或对抗作用.

研究的目的:

研究多种维生素同时暴露模式对糖尿病患者全因死亡风险的影响.
探索不同的人口分组中这些影响的变化.

主要方法:

利用了2003-2006年国家健康和营养检查调查 (NHANES) 中糖尿病患者 (年龄≥20岁) 的数据.
采用K-介质聚类来识别对八种血清维生素同时暴露的模式.
应用了考克斯的比例危险模型来评估维生素同时暴露模式与全因死亡率之间的关联.

主要成果:

确定了三种同时暴露模式 (低,中等,高).
与低水平暴露相比,多种维生素的高水平同时暴露与所有原因死亡风险的显著降低有关 (HR:0.42;95% CI:0.20,0.87).
亚组分析显示,男性,60岁以上的个体和非西班牙裔白人糖尿病患者与高维生素同时暴露显著降低风险.

结论:

对多种维生素的高水平联合暴露在糖尿病患者中具有显著的生存益处.
糖尿病的维生素干预策略应考虑到营养素的综合摄入量和特定人群的差异.
需要进一步研究多种维生素与不同人群健康结果的复杂相互作用.

关键词:

共同暴露共同暴露糖尿病糖尿病患者糖尿病患者死亡率死亡率风险风险风险风险风险维生素维生素维生素是一种

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