激素的分子机制与偏头痛有关,以及对跨性别患者的转化影响
Cameron I Martinez1, Erika Liktor-Busa1, Tally M Largent-Milnes1
1Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States.
Frontiers in pain research (Lausanne, Switzerland)
|October 5, 2023
概括
性激素显著影响偏头痛的病理生理学. 这篇评论探讨了雌激素,孕和以及其他激素如何影响 cisgender 和跨性别人口的偏头痛.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 疼痛医学 医学 疼痛医学
背景情况:
- 偏头痛是一种使人衰弱的神经系统疾病,在女性中更为普遍,这表明性激素的作用.
- 雌激素,孕和都与慢性疼痛有关,而雄激素可能会提供保护.
研究的目的:
- 在偏头痛病理生理学中审查主要淋巴腺激素 (雌激素,孕,) 的分子机制.
- 介绍有关次要性激素 (益生素,LH,FSH,GnRH) 和它们在偏头痛中的作用的文献.
- 讨论性激素研究对接受激素替代疗法 (HRT) 的跨性别和性别不符合 (变性*) 个体的偏头痛管理的影响.
主要方法:
- 关于性激素和偏头痛的现有研究的综合文献综述.
- 对将性腺和小性激素与偏头痛联系起来的分子机制的分析.
- 将发现推断到接受HRT的跨性别患者群体.
主要成果:
- 主要的淋巴腺激素 (雌激素,孕,) 在偏头痛病理生理学中表现出复杂的作用.
- 较小的性激素如益生素,LH,FSH和GnRH也会影响偏头痛的发生率和严重程度.
- 了解这些荷尔蒙的影响对于治疗 cisgender 和 trans* 个体的偏头痛至关重要.
结论:
- 性激素是偏头痛的关键调节剂,影响偏头痛的发病率和表现.
- 需要进一步的研究来优化偏头痛治疗策略,用于HRT的 cisgender 女性和跨性别人士.
- 这一综述强调了在全面的偏头痛护理中考虑激素因素的重要性.
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