ASIC3在运动期间通过肌肉酸性感觉在延迟发作的肌肉疼痛 (DOMS) 中起着保护作用
Tahsin Khataei1,2,3, Christopher J Benson1,2
1Department of Internal Medicine, Roy J and Lucile A. Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Frontiers in pain research (Lausanne, Switzerland)
|October 5, 2023
概括
酸感应离子通道 (ASICs) 对立即运动诱导疼痛 (IEIP) 至关重要,但对延迟肌肉疼痛 (DOMS) 不至关重要. 缺少ASIC3可以防止IEIP,并可能防止运动引起的肌肉损伤.
科学领域:
- 运动生理学 运动生理学
- 疼痛研究 疼痛研究
- 分子生物学分子生物学
背景情况:
- 运动引起的肌肉疼痛,包括即时疼痛 (IEIP) 和延迟发作的肌肉疼痛 (DOMS),可以阻碍身体活动.
- 酸感应离子通道 (ASIC) 涉及慢性疼痛,但它们在急性运动疼痛中的具体作用尚未完全理解.
研究的目的:
- 研究ASIC3在即时运动诱导疼痛 (IEIP) 中的作用.
- 确定ASIC3是否对于延迟发作的肌肉疼痛 (DOMS) 的发展是必要的.
主要方法:
- 使用野生型 (WT) 和ASIC3缺陷 (ASIC3-/-) 的小鼠接受了详尽的跑步机运动.
- 使用肌肉退出值 (MWT) 评估肌肉疼痛,在运动后立即和24小时.
- 通过运动运动活动,握力和重复运动性能测试来评估DOMS.
主要成果:
- 与WT小鼠不同,ASIC3-/-小鼠没有表现出IEIP,这表明ASIC3是这种即时疼痛反应所需的.
- 无论是WT和ASIC3-/-小鼠都经历了DOMS,这表明ASIC3对DOMS并不重要.
- 与运动后的WT小鼠相比,ASIC3-/-小鼠的肌肉损伤标志物 (LDH,CK) 增加,恢复受损.
结论:
- ASIC3是即时运动诱导疼痛 (IEIP) 的关键调解者.
- 对于延迟发作的肌肉疼痛 (DOMS) 的发展,不需要ASIC3.
- ASIC3可能在减轻强度运动后肌肉损伤方面发挥保护作用.
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