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治疗宫癌IIIC2阶段的治疗方法:应该期待什么?

Geovanne Pedro Mauro^1,2, Vinicius de Aquino Calheiros¹, Matheus Sorgi Vonsowski¹

¹Department of Radiology and Oncology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

|October 5, 2023

概括

晚期宫癌患者具有阳性准大动脉淋巴结可以实现长期生存. 建议同时进行化学辐射和支架疗法,而表现不佳的状态表明风险更高.

科学领域:

妇科瘤学妇科瘤学
辐射瘤学辐射瘤学
医学瘤学医学瘤学

背景情况:

在晚期子宫癌中,阳性准大动脉淋巴结 (PAN) 存在治疗挑战.
患有PAN的患者经常被排除在临床试验之外,限制了基于证据的治疗指南.
这项研究解决了缺乏关于PAN宫癌患者最佳治疗和预后因素的数据.

研究的目的:

报告晚期子宫癌患者的结果,在一个机构治疗的阳性PAN.
为了确定影响该患者队列生存的变量.
建立对阳性PAN宫癌的潜在标准治疗方案.

主要方法:

从2010年4月至2017年5月接受治疗的65名阳性PAN患者的回顾性评估.
评估人口变量和治疗方式.
对整体存活率 (OS),局部区域控制,远程无转移存活率和PAN进展的影响分析.

主要成果:

中位数的生存期为38.7个月;中位数的局部区域和PAN无进展生存期没有达到.
没有远程转移的中位数生存时间为64.3个月.
更好的ECOG性能状态,并发化疗和支臂治疗独立地与改善的OS相关.

结论:

具有阳性PAN的IIIC2期宫癌患者可以实现长期生存.
同时使用化学辐射和支架疗法应被视为标准的治愈意向治疗.
糟糕的表现状况和晚期的盆腔疾病与更糟糕的结果相关;远程转移仍然是一个挑战.

关键词:

支臂疗法 (brachytherapy) 是一种治疗方法.宫癌:子宫癌是一种癌症.准大动脉上的人.回性皮质淋巴结的淋巴结.

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