异构分析算法 (AAA) 和Acuros XB (AXB) 之间的剂量差异由目标空气含量引起,用于脑癌体积调制弧线治疗
Takaaki Ito1,2, Hajime Monzen1, Kazuki Kubo1
1Department of Medical Physics, Graduate School of Medical Sciences, Kindai University, Osakasayama, Osaka, Japan.
概括
异构分析算法 (AAA) 和Acuros XB (AXB) 之间的剂量差异随着规划目标体积 (PTV) 中空气含量增加而增加. 当空气含量超过5%时,Acuros XB (AXB) 显示剂量升级.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
背景情况:
- 剂量计算算法对于准确的放射治疗计划至关重要.
- 无otropic分析算法 (AAA) 和 Acuros XB (AXB) 是两个常见的剂量计算算法.
- 了解它们的差异,特别是在异质的环境中,如有空气腔的环境,对于临床实践至关重要.
研究的目的:
- 为了量化AAA和AXB算法之间的剂量差异,随着目标空气含量增加.
- 评估空气含量对体积调制弧线治疗 (VMAT) 中头癌 (HNC) 剂量处方和输送的影响.
主要方法:
- 在规划目标体积 (PTV) 内的空气含量变化的虚拟幻影被使用.
- 使用AAA和AXB算法重新计算了整个部VMAT计划.
- 剂量指标 (D98%,D95%,D50%,D2%) 在算法之间进行了比较.
- 对不同空气/PTV百分比的临床病例进行了监测单位 (MU) 的比较.
主要成果:
- AAA和AXB之间的剂量差异随着空气/PTV的增加从5%增加到30%.
- 对于D95%,剂量差异在2.35%至13.92%之间.
- 当空气/PTV为5%或以上时,Acuros XB (AXB) 显示剂量比AAA升级.
结论:
- AAA和AXB剂量计算之间的差异随着目标中的空气含量增加而增加.
- 与AAA相比,AXB可能会导致剂量升级,在具有显著空气空洞的目标中.
- 使用AXB对100%的PTV减去空气含量进行处方,结果与AAA的D95%处方相提并论.
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