在接受基于多卢特格拉维尔的治疗方案的HIV阳性患者中,神经认知能力的改善
Janine Rodrigues1, Karishma Lowton1
1Department of Psychiatry, Faculty of Medicine, University of the Witwatersrand, Johannesburg, South Africa.
概括
基于多卢特格拉维尔的抗逆转录病毒疗法 (ART) 显示出改善先前未接受治疗的艾滋病毒患者的神经认知功能的前景. 这项研究观察到,在多卢特格拉维尔ART治疗3个月后,认知能力显著改善,支持其在艾滋病毒相关的神经认知障碍 (HAND) 中的使用.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 尽管有效的抗逆转录病毒疗法 (ART),神经认知障碍,特别是轻微的形式,在感染人类免疫缺陷病毒 (HIV) 的个体中仍然很普遍.
- 基于多卢特格拉维尔的疗法是成年艾滋病毒患者的主要治疗方法,但关于其神经认知效应存在争议.
- 关于多卢特格拉维尔对神经认知功能影响的证据对于管理与艾滋病毒相关的神经认知障碍 (HAND) 至关重要.
研究的目的:
- 为了评估艾滋病毒阳性,未经治疗的患者的认知功能变化.
- 为了评估认知变化3个月后启动ART与dolutegravir基础的治疗方案.
- 使用国际艾滋病毒痴呆症量表 (IHDS) 和简要神经心理认知检查 (BNCE) 进行认知评估.
主要方法:
- 进行了一项前性定量队列研究.
- 没有接受过治疗的成年艾滋病毒阳性患者开始使用基于多卢特格拉维尔的治疗方案.
- 在基线和ART治疗3个月后使用BNCE和IHDS评估认知功能.
主要成果:
- 在IHDS得分 (p=0.033) 和完成BNCE的时间 (p=0.007) 中观察到显著的改善.
- 虽然BNCE的整体结果没有达到统计学意义 (p=0.075),但BNCE的第二部分反映了执行职能,显示了显著的改善 (p=0.043).
- 神经认知测试结果显示,26名参与者出现了积极的趋势.
结论:
- 这项研究表明,艾滋病毒阳性,以前未接受治疗的患者接受为期3个月的基于杜洛特格拉维尔的ART,神经认知功能有所改善.
- 研究结果支持使用基于杜洛特格拉维尔的疗法来管理与艾滋病毒相关的神经认知障碍 (HAND).
- 多卢特格拉维尔可能是ART治疗艾滋病毒患者认知健康的有益成分.
相关概念视频
Retrovirus Life Cycles
46.1K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.1K
Alzheimer's Disease: Treatment
212
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
212
Parkinson's Disease: Treatment
287
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
287
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
310
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
310
Alzheimer's Disease: Overview
506
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
506
Negative and Cognitive Symptoms of Schizophrenia
54
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
54


