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在MSS的器官保存直肠癌直肠癌

Yuye Gao¹, Aiwen Wu¹

¹Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Unit III, Gastrointestinal Cancer Center, Peking University Cancer Hospital and Institute, Beijing, China.

Clinics in colon and rectal surgery

|October 5, 2023

概括

器官保存是微卫星稳定 (MSS) 的直肠癌患者在新辅助疗法后获得临床完整反应 (cCR) 的可行选择. 这种方法提供了与手术可比的结果,降低了发病率,但需要进一步的研究.

科学领域:

在瘤学瘤学.
胃肠病学胃肠病学
手术瘤学手术瘤学

背景情况:

结直肠癌表现出多种不同的遗传和分子亚型.
新辅助疗法改善了微卫星稳定性直肠癌 (MSS) 的反应率.
MSS直肠癌仅对免疫检查点抑制剂的反应有限.

研究的目的:

评估器官保存作为MSS直肠癌激进手术的替代方案.
评估新辅助疗法后非手术治疗的可行性和结果.
确定患者选择策略,以最大限度地提高器官保存的成功.

主要方法:

对MSS直肠癌中新辅助治疗结果的审查.
对器官保存策略的分析,包括非手术管理和手术.
器官保存与激进手术之间的瘤和发病率结局的比较.

主要成果:

对于在新辅助治疗后获得临床完整响应 (cCR) 或接近cCR的患者来说,器官保存是可行的.
癌症的结果似乎不低于激进手术,术后发病率显著降低.
患者选择,无论是治疗前还是治疗后,对于有利的结果至关重要.

结论:

器官保存是选择MSS直肠癌患者的安全有效策略.
非手术治疗和器官保存手术为彻底切除提供了一个有希望的替代方案.
需要进一步的研究来优化瘤回归并扩大器官保存的可能性.

关键词:

地方切除法地方切除法微卫星稳定的微卫星器官的保存器官的保存这是直肠癌.观看和等待等待.

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