在血液恶性瘤的免疫功能低下患者中,可活性的SARS-CoV-2的长期泄露:一项前性研究
Takaya Ichikawa1,2,3, Tomokazu Tamura1,4, Mutsumi Takahata5
1Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
British journal of haematology
|October 5, 2023
概括
长时间的SARS-CoV-2感染是免疫功能低下患者的一个担忧. 这项研究在19.2%的患有血液性恶性瘤的患者中发现了可活性病毒,这与较低的CD4+T细胞计数和特定化疗有关.
科学领域:
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 长时间的SARS-CoV-2感染在免疫功能受损的个体中,由于不清楚的病毒分泌模式,会带来挑战.
- 患有血液性恶性瘤的患者特别容易受到严重和持续的COVID-19的影响.
研究的目的:
- 为了研究SARS-CoV-2的病毒分泌动力学和特征,在患有血液性恶性瘤的免疫受损患者中.
- 为了确定与这种患者队列中长期病毒分泌相关的潜在风险因素.
主要方法:
- 一项前性研究涉及26名患有血液性恶性瘤的COVID-19患者.
- 鼻抽样是在发病后21-28天收集的,用于PCR测试和病毒隔离.
- 分析CD4+T细胞计数,并比较之前的化疗方案.
主要成果:
- 在19.2%的患者 (26人中5人) 中检测到一种可活的SARS-CoV-2病毒.
- 检测到可活性的病毒的所有患者都有恶性淋巴瘤和显著降低的CD4+T细胞计数.
- 以往使用抗CD20抗体和本达穆斯丁的治疗被确定为延长病毒分泌的潜在风险因素.
结论:
- 恶性淋巴瘤和降低的CD4+T细胞计数与免疫功能低下的患者中可活的SARS-CoV-2的存在有关.
- 特定的化疗药物,包括抗CD20抗体和本达穆斯丁,可能会增加长期病毒分泌的风险.
- 需要进行进一步的研究,以了解长时间的病毒分泌对这种人群的治疗和传播的影响.
相关概念视频
Immunodeficiency Diseases
963
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
963
Pulmonary Tuberculosis I
249
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
249
Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K


