冬眠地松鼠神经肌肉结合形态和相关调节蛋白质的可塑性变化
Yue He1,2, Hui-Ping Wang1,2, Fang-Yang Pan1,2
1Shaanxi Key Laboratory for Animal Conservation, College of Life Sciences, Northwest University, Xi'an, People's Republic of China.
Journal of applied physiology (Bethesda, Md. : 1985)
|October 5, 2023
概括
冬眠的达鲁亚地松鼠表现出肌肉可塑性. 唯一的肌肉是唯一的肌肉.
科学领域:
- * 神经生物学 神经生物学
- *比较生理学 *比较生理学
- * 骨肌肉研究
背景情况:
- * 废弃缩可以降低神经肌肉结 (NMJs).
- * 达乌里亚地松鼠是研究冬眠期间肌肉缩的自然模型.
- * 冬眠期间的NMJ形态和调节尚不清楚.
研究的目的:
- * 在冬眠期间,研究达乌里亚地松鼠缓慢抽 (soleus) 和快速抽 (extensor digitorum longus) 肌肉中的NMJ形态.
- * 检查关键NMJ维护通路组件的表达 (Agrin, Lrp4).
主要方法:
- * 索莱斯肌和延伸指长长肌肌中NMJs的形态分析.
- * Lrp4和Agrin表达水平的量化.
- * 冬眠前期,冬眠期 (昏昏欲睡,间接兴奋) 和冬眠后期的比较.
主要成果:
- * Soleus 肌肉 NMJ 形态在冬眠期间下降,但在冬眠后恢复.
- * 低密度脂蛋白受体相关蛋白4 (Lrp4) 表达在交叉激发期间在单体中减少.
- * 在间隔激发过程中,扩展指纹长 (extensor digitorum longus) 的阿格林表达增加,保持NMJ形态.
结论:
- * 冬眠会诱导单体NMJs显著的可塑性,涉及LRp4调节.
- * 增加的阿格林表达可能会在冬眠期间保护快速抽肌肉NMJs.
- *NMJ可塑性是抵御冬眠动物的不使用缩的关键机制.
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