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纳米粒子和纳米拓学诱导的Wnt途径在骨再生中的激活

Chitra Jagannathan¹, Rachel Waddington², Wayne Nishio Ayre²

¹Department of Applied Sciences, University of the West of England, Bristol, United Kingdom.

Tissue engineering. Part B, Reviews

|October 5, 2023

概括

纳米粒子和纳米拓图激活了Wnt途径,通过内细胞化,整合素信号和离子释放来进行骨再生. 了解这些机制有助于开发针对性的纳米级骨修复技术.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
细胞信号传递细胞信号传递

背景情况:

纳米粒子和纳米拓技术对于骨再生至关重要.
无翼相关集成部位 (Wnt) 信号通路对于骨质生分化和扩散至关重要.
纳米级材料激活Wnt通路的机制尚未完全理解.

研究的目的:

阐明纳米技术在骨再生过程中激活Wnt信号通路的机制.
审查关于Wnt信号,骨再生和纳米拓图/纳米粒子的原始研究文章.

主要方法:

在PubMed和Ovid上进行系统的文献搜索,使用'Wnt','bone'和'nano*'的术语.
在纳米拓和纳米颗粒的背景下,重点关注骨再生中的Wnt信号的原始研究文章的综述.
分析不同纳米结构激活Wnt通路的机制.

主要成果:

纳米粒子通过内部化 (内细胞化/扩散) 激活Wnt,增加细胞质β-catenin和骨质生成信号 (例如RUNX2).
纳米拓直接激活的受体,并可以通过特定的细胞组件激活Wnt/Ca2+和Wnt/平面细胞极性通路.
具有纳米拓图/纳米粒子的支架通过离子释放 (抑制GSK-3β) 和纳米拓特异性机制诱导Wnt信号.

结论:

纳米粒子和纳米图形通过多种结构特定的机制激活Wnt信号.
关键的机制包括内细胞结合 (纳米颗粒),整蛋白信号 (纳米图谱) 和离子释放 (支架).
了解这些途径将使得开发先进的纳米级骨再生疗法成为可能.

关键词:

没有信号通路.骨再生骨再生细胞的分化和粘附.纳博图形图形学 (nabotopography) 是一种图形图形学.纳米颗粒是一种纳米粒子.脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架.

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