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长非编码RNA在三阴性乳腺癌中的作用

Plabon Kumar Das^1,2, Ayesha Siddika³, Khan Mohammad Rashel¹

¹Department of Biochemistry & Molecular Biology, Rajshahi University, Rajshahi, Bangladesh.

Cancer medicine

|October 5, 2023

概括

长非编码RNAs (lncRNAs) 是攻击性三阴性乳腺癌 (TNBC) 的关键参与者. 本综述探讨了lncRNAs如何影响TNBC发育,治疗耐药性和患者的结果,突出了潜在的治疗点.

科学领域:

分子瘤学分子瘤学
基因组学就是基因组学.
癌症生物学癌症生物学

背景情况:

三阴性乳腺癌 (TNBC) 是一种具有不良预后的侵袭性亚型.
由于缺乏针对TNBC的向疗法,因此需要新的治疗策略.
长非编码RNAs (lncRNAs) 越来越多地被认为是它们在癌症中的调节作用.

研究的目的:

审查有关lncRNAs在TNBC病变发生中的作用的当前文献.
阐明 lncRNAs 导致 TNBC 疗法耐药性的机制.
讨论针对TNBC中的lncRNAs的预后影响和治疗潜力.

主要方法:

关于研究TNBC中 lncRNAs 的综合文献综述.
对 lncRNA 作用的分子机制的分析 (诱,脚手架,海绵).
检查 lncRNA 参与药物耐药性途径的研究 (例如,ABCB1).

主要成果:

特定的lncRNAs (例如,SNHG12,HULC,HOTAIR,LincRNA-ROR) 的异常表达与TNBC病变发生有关.
lncRNAs调节基因表达和信号通路,这对TNBC进展至关重要.
某些lncRNAs (例如,FTH1P3,BORG) 通过影响药物流量和DNA修复来赋予治疗耐药性.

结论:

lncRNAs是TNBC病变发生,治疗耐药性和预后的关键调节者.
了解 lncRNA 功能,可以了解 TNBC 生物学.
向lncRNAs是一个有前途的治疗策略,用于攻击性的TNBC.

关键词:

抗化学疗法耐药性抗化学疗法耐药性长长的非编码RNAs.病变的发生和发病.预后预后预后抗辐射疗法耐药性抗辐射治疗耐药性有针对性的治疗方法.

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