大规模的功能网络连接介绍了2型糖尿病中脂质代谢和认知之间的关联
Wen Zhang1,2,3, Linqing Fu1, Yan Bi4
1Department of Radiology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
2型糖尿病 (T2D) 与大脑网络连接的改变有关. 调节血清脂质可以通过增强大脑网络通信来改善T2D患者的认知功能.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 医疗成像医学成像
背景情况:
- 2型糖尿病 (T2D) 经常伴有脂质障碍和认知障碍.
- 了解代谢功能障碍,大脑功能和T2D认知之间的相互作用对于开发有针对性的干预措施至关重要.
研究的目的:
- 为了研究血清脂质代谢,认知功能和功能连接 (FC) 在T2D患者的大脑网络内和大脑网络之间之间的关系.
- 探索大脑网络FC在T2D中脂质代谢和认知之间的关联中的调解作用.
主要方法:
- 功能性磁共振成像 (fMRI) 用于评估102名T2D患者和45名健康对照者的脑网络FC.
- 参与者接受了脂质特征测试和全面的认知评估.
- 独立组件分析 (ICA) 确定了13个功能网络,统计分析包括MANCOVA,部分相关性,正统相关性和调解分析.
主要成果:
- 在T2D患者中观察到显著减少的网络间FC,特别是在腹部感觉运动网络 (SMN) 和背部注意网络 (DAN) 之间,以及腹部SMN和侧面视觉网络 (VN) 之间.
- 较低的网络间FC与较差的脂质代谢和认知表现相关.
- 网络间的FC显著调解了脂质代谢和认知功能之间的关系 (β = -0.3136). 在前置默认模式网络,DAN和侧面VN中改变的网络内部FC与全球认知正相关.
结论:
- 在T2D中,失脂症与大脑网络功能连接的广泛中断有关.
- 大脑网络之间的功能连接和大脑网络内的功能连接在调解脂质代谢对T2D认知功能的影响方面发挥着关键作用.
- 准脂质代谢可能是改善2型糖尿病患者认知功能的可行策略.
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