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[¹⁸F]LW223在小鼠大脑中具有较低的不可取代的结合,使得高灵敏度的TSPO PET成像成为可能

Agne Knyzeliene^1,2, Mark G MacAskill^1,2, Carlos J Alcaide-Corral^1,2

¹BHF-University of Edinburgh Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

|October 5, 2023

概括

一种新的PET追踪器[18F]LW223,显示低非可取代的结合和代谢,使其适合用于神经炎症成像. 在大脑PET研究中,简化量化方法对这种转位蛋白 (TSPO) 标记物是可行的.

科学领域:

神经科学是一个神经科学.
放射化学放射化学是指辐射化学.
医疗成像医学成像

背景情况:

神经炎症是各种大脑疾病的关键因素.
转位蛋白 (TSPO) 是PET成像中神经炎症的验证生物标志物.
开发新的PET射线追踪剂对于准确的疾病诊断和监测至关重要.

研究的目的:

在小鼠中评估 TSPO PET 新型放射追踪器 [18F]LW223 的结合动力学.
为了确定大脑中[18F]LW223的不可取代结合 (VND) 的体积.
探索 [18F]LW223 PET 数据的简化量化方法.

主要方法:

在成年雄性小鼠中体内PET成像,注射了[18F]LW223.
用不同的LW223度进行剂量依赖的阻断研究,以估计VND.
动态PET成像与动脉输入功能和放射性代谢物分析.
对SUV和V Tapp等简化量化方法的评估.

主要成果:

[18F]LW223表现出低脑VND (<10%) 和低辐射代谢 (~15-20%).
2组织区模型最好地描述了PET数据.
简化方法 (SUV90-120min,V Tapp) 与在健康动物中量化2组织区模型相对应得很好.

结论:

[18F]LW223对TSPO PET射线追踪器具有有利的特性.
对于健康受试者的[18F]LW223 PET数据,简化量化方法是可行的.
这种追踪器对神经炎症成像和研究具有前景.

关键词:

在这里,PET是PET.在 TSPO TSPO 中.VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND VND [18F]LW22333 的时间.脑子脑子脑子大脑

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