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Updated: Jul 15, 2025

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
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核包装组装依赖CHMP-7在没有BAF-LEM介导的孔封闭的情况下

Sarah R Barger1, Lauren Penfield1, Shirin Bahmanyar1

  • 1Yale University, Department of Molecular, Cellular, Developmental Biology, 266 Whitney Ave., New Haven, CT 06511, USA.

Journal of cell science
|October 5, 2023
PubMed
概括

屏障与自集成因子 (BAF) 蛋白质和LEM域蛋白质在围绕轴微管周围的核外 (NE) 孔封闭中发挥着不同的作用. 涉及BAF-LEM结合和LEM-2-CHMP-7的冗余机制确保NE组装和胚胎存活.

关键词:
在BAF中,BAF是BAF.这是ESCRT的特点.这是一个LEM域名.核包裹是一个核包裹.

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