药物可能会增加被诊断为前列腺癌的风险
Aldo Brassetti1, Francesco Tedesco2, Loris Cacciatore3
1Department of Urology, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.
Minerva urology and nephrology
|October 5, 2023
概括
在一项回顾性研究中,他类药物的使用与前列腺癌 (PCa) 诊断的可能性更高有关. 然而,他类药物与更高度的前列腺癌没有显著的相关性.
科学领域:
- 在瘤学瘤学.
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 类药物主要以心血管保护而闻名,具有抗炎性质.
- 这些抗炎作用表明,在癌症预防方面,包括瘤发生在内,有潜在的作用.
研究的目的:
- 调查他类药物摄入量与前列腺癌 (PCa) 诊断之间的关联.
- 评估他类药物使用与PCa的攻击性之间的关系.
主要方法:
- 对1685名接受前列腺活检的患者 (2008年12月至2022年12月) 的回顾性分析.
- 后勤回归分析评估了代谢综合征 (MetS),他类药物使用,PCa诊断和高等级 (HG) 疾病 (预后等级组≥3) 之间的关联.
主要成果:
- 静止剂的使用独立地与PCa诊断的风险增加有关 (OR 1.44;P=0.02).
- 与对照组相比,服用他类药物的男性 (46.8%) 的瘤发病率较高 (37.8%;P=0.002).
- 达丁类药物摄入量没有显著预测高度疾病 (P=0.8).
结论:
- 达丁类药物的使用可能与前列腺癌的风险增加有关.
- 该研究没有发现他类药物的使用与前列腺癌的攻击性之间存在显著的关联.
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