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功能性磁共振成像在冠状病毒疾病2019年诱导的嗅觉功能障碍

Kamyar Iravani¹, Behzad Malekpour¹, Alireza Rasekhi²

¹Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.

The Journal of laryngology and otology

|October 5, 2023

概括

冠状病毒疾病2019 (COVID-19) 患有嗅觉丧失的患者在关键的嗅觉处理区域的脑活动减少. 功能性MRI揭示了这些个体的上额叶和基底腺节的较低激活.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
传染性疾病传染性疾病

背景情况:

嗅觉功能障碍是2019年冠状病毒疾病 (COVID-19) 的常见症状.
在COVID-19后持续的气味丧失的潜在神经机制需要进一步调查.
功能磁共振成像 (fMRI) 提供了一种非侵入性方法来研究大脑活动.

研究的目的:

调查COVID-19患者的嗅觉结构中的功能磁共振成像 (fMRI) 变化.
为了将这些大脑变化与持续的嗅觉功能障碍相关联.
为了确定受COVID-19引起的气味丧失影响的特定大脑区域.

主要方法:

包括已确诊的COVID-19和持续的嗅觉功能障碍 (≥2个月) 的成年患者 (25-65岁).
排除了因嗅觉功能障碍而接受任何治疗的患者.
利用功能磁共振成像 (fMRI) 来评估嗅觉结构中的大脑激活模式.

主要成果:

患有COVID-19相关的嗅觉功能障碍的患者在上额叶的活化显著减少.
分析显示,受影响患者的基底腺节激活率显著降低.
这些大脑区域的尺寸 (累计最大直径) 和激活点的数量都显著减少.

结论:

冠状病毒疾病2019年触发的嗅觉功能障碍与上额叶神经活动减弱有关.
由于COVID-19而经历嗅觉丧失的患者表现出基底质活动减少.
这些发现突显了COVID-19感染后大脑嗅觉通路的特定神经生物学变化.

关键词:

新冠病毒新冠病毒新冠病毒.诊断成像诊断成像的使用.磁共振成像技术的使用人们的生活质量.味道味道味道味道味道

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