在儿科炎症性肠病中使用生长激素
Melissa Crisci1, Srisindu Vellanki1, Robert N Baldassano1,2
1The Children's Hospital of Philadelphia, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Philadelphia, PA, USA.
Journal of pediatric endocrinology & metabolism : JPEM
|October 5, 2023
概括
增长激素 (GH) 治疗显著改善了炎症性肠病 (IBD) 的儿科患者的身高结果. 这项研究显示,在一年后和完成IBD相关生长障碍的GH治疗后,高度z-score得到改善.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 内分泌学 在内分泌学.
- 增长障碍 发展障碍 发展障碍
背景情况:
- 线性生长障碍是儿科炎性肠病 (IBD) 的已知的并发症.
- 增长激素 (GH) 治疗儿童IBD患者生长缺陷的疗效没有得到广泛的证据.
研究的目的:
- 评估生长激素 (GH) 治疗对IBD诊断的儿童和青少年身高结果的影响.
- 为了确定GH治疗是否会在这个特定的患者群体中显著改善身高z-score.
主要方法:
- 儿科IBD患者 (0-21岁) 的回顾性图表审查,在2018-2021年期间至少一年接受GH治疗.
- 收集的数据包括人口统计,IBD特征,疾病活性,药物,体重和身高z-scores,骨龄和GH治疗细节.
- 主要结局是GH管理一年后身高z-score的变化.
主要成果:
- 分析包括28名儿科IBD患者 (26名克罗恩氏病,2名性结肠炎患者).
- 经过一年的GH治疗 (从-2.25到-1.50,p<0.001) 后,观察到身高z-score的平均显著增加.
- 完成GH治疗的患者在身高z-score上显著改善 (从-2.41到-0.77,p<0.001).
结论:
- 增长激素 (GH) 治疗与炎症性肠病 (IBD) 的儿科患者身高结果的显著改善有关.
- 这些发现支持使用GH作为治疗选择来解决儿科IBD中生长障碍.
- 儿科IBD患者在GH治疗期间和之后在身高z-score上表现出显著的增长.
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