优化配方参数,用于开发可注射卡维迪洛的in situ形成仓库
Majd Alrashdan1, Ziad A Shraideh2, Samer R Abulateefeh1
1School of Pharmacy, The University of Jordan, Amman, Jordan.
Pharmaceutical development and technology
|October 5, 2023
概括
这项研究开发了一种新的可注射的长效卡维迪醇在位形成仓库 (ISFD) 系统. 聚合物选择允许可调节的药物在30天内释放,为慢性疾病管理提供了一个有希望的替代方案.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 传统的持续药物输送系统面临着局限性.
- 卡维迪洛尔是治疗慢性疾病的每日药物,其半衰期很短.
- 可注射在位形成仓库 (ISFD) 提供了一个替代的药物输送方法.
研究的目的:
- 开发和描述一种新的可注射的长效卡维迪洛尔-ISFD配方.
- 评估聚合物性质 (乳和糖的比率和终端功能) 对ISFD性能的影响.
- 研究有机溶剂对仓库形成和药物释放的影响.
主要方法:
- 用于制备ISFD的四种类型的聚合物 (PLGA和PLA与酸或覆盖) 用于制备ISFD.
- 各种有机溶剂 (NMP,DMSO,乙烯酸,基酸) 被选为仓库的形成.
- 在30天内评估了封装效率和体外药物释放概况.
主要成果:
- 证明N-甲基-2-pyrrolidone (NMP) 和二甲基硫氧化物 (DMSO) 适用于仓库形成.
- 所有ISFD配方都实现了高封装效率 (96-98%).
- 基于PLGA的ISFD在30天内延长了卡维迪醇的释放时间,而基于PLA的ISFD则释放速度较慢 (36-60%).
结论:
- 可以注射的卡维迪-ISFDs已成功开发,具有可调节的延长释放特性.
- 聚合物等级的选择 (PLGA与PLA,端盖) 显著影响了药物释放动力学.
- 这项技术呈现了一种新的可注射配方,用于长效卡维迪醇的输送.
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