对过敏儿童的SARS-CoV-2抗体进行了回顾性研究
Yuri Takaoka1,2, Yosuke Baba1,2, Shun Toriumi2
1Department of Pediatrics, Juntendo University Shizuoka Hospital, Shizuoka, Japan.
概括
儿科过敏患者对SARS-CoV-2的抗体患病率较低,但随着时间的推移而增加. 大多数感染是亚临床的,在学龄儿童中患病率更高.
科学领域:
- 儿科过敏和免疫学
- 传染病 流行病学 流行病学
背景情况:
- 儿童感染SARS-CoV-2的动态正在演变.
- 在儿科过敏患者中评估SARS-CoV-2抗体的流行率至关重要.
研究的目的:
- 为了确定SARS-CoV-2抗体在过敏儿童中的患病率.
- 为了评估抗体水平在一年内发生的变化.
主要方法:
- 对310名患有过敏症状的儿童 (<11岁) 进行了回顾性研究.
- 对抗SARS-CoV-2IgG和IgM抗体进行定性测试.
- 一年后进行后续测试,以评估抗体水平的变化.
主要成果:
- 32名患者 (10.3%) 检测出SARS-CoV-2抗体呈阳性.
- 在学龄前/学龄儿童中观察到更高的抗体患病率 (OR:13.19).
- 在研究期间,抗体阳性率增加,而不依赖于过敏严重程度.
结论:
- 在儿科过敏患者中,SARS-CoV-2抗体患病率较低但在增加.
- 大多数阳性病例是亚临床的,没有先前的COVID-19诊断.
- 学校/学前教育的招生与更高的抗体患病率有关.
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