体重和肥胖对食道功能的影响
1Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, China.
Physiological research
|October 5, 2023
概括
肥胖会对食道功能产生负面影响,减少粘膜屏障的完整性和改变运动性. 较高的体重指数与酸性反流增加和食道功能受损相关.
科学领域:
- 胃肠病学 胃肠病学
- 消化系统健康 消化系统健康
- 肥胖问题研究研究
背景情况:
- 全球肥胖率的上升带来了重大的健康挑战.
- 肥胖与消化系统并发症有关,包括胃食道逆流症.
- 不同程度的肥胖对食道功能的具体影响仍未得到充分研究.
研究的目的:
- 研究不同类别的体重指数 (BMI) 对食道粘膜屏障完整性和运动性的影响.
- 分析正常体重,超重和肥胖个体食道功能指标的差异.
主要方法:
- 对611名参与者的回顾性分析,按BMI分类.
- 使用高分辨率食道测量仪 (HREM) 和24小时pH阻抗监测数据.
- 与BMI相关的食道粘膜屏障,运动性和酸性反流指标.
主要成果:
- 在超重和肥胖群体中观察到较低的平均夜间基线阻抗 (MNBI),表明粘膜完整性降低.
- 在肥胖组中增加了酸暴露时间 (AET),DeMeester分数 (DMS) 和反流发作.
- 在超重和肥胖群体中,上食管 (UES) 余压,腹内压 (IBP),下食管 (LES) 静止压,食管胃结合合收缩整体 (EGJ-CI) 的升高.
结论:
- 体重增加显著影响食道粘膜的完整性.
- 不同程度的肥胖与食道运动和功能的明显改变有关.
- 研究结果强调肥胖对食道健康的有害影响,影响食道运动和屏障功能.
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