乳糖与聚乙烯糖醇用于肠道准备:基于BMI的单中心,前性,随机对照性研究
Sun Wenqi1, Zhao Bei, Wang Yunrong
1Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing City, P.R. China.
Clinical and translational gastroenterology
|October 5, 2023
概括
与聚乙烯糖醇 (PEG) 相比,乳糖醇口服液为结肠镜检查提供了优越的肠道准备,特别是在正常或更高BMI的个体中. 这导致了更好的病变检测和更少的不良影响,使其成为一个有希望的选择.
科学领域:
- 胃肠病学 胃肠病学
- 临床医学 临床医学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 高质量的结肠镜取决于有效的肠道准备.
- 不充分的准备可以导致错过或误诊断的结直肠病变.
- 选择安全有效的口服药对于最佳的结肠镜检查结果至关重要.
研究的目的:
- 为了比较乳糖口服溶液和聚乙烯糖醇 (PEG) 电解质粉用于结肠镜肠道制备.
- 评估这些药物的有效性和安全性在不同的身体质量指数 (BMI) 类别.
- 评估患者的满意度和与每个制备方法相关的不良影响.
主要方法:
- 采用了前性随机对照研究设计.
- 关键指标包括波士顿肠准备量表,肠泡泡评分,腺瘤检测率,患者满意度和不良事件.
- 参与者根据体重指数 (BMI) 进行了分层分类,以分析试剂的适用性.
主要成果:
- 与PEG相比,乳糖显著改善了肠道制备质量 (P < 0.05),特别是在正常和较高的BMI组.
- 在乳糖组中,腺瘤检测率明显高于乳糖组 (50%对33.5%,P<0.05).
- 乳糖也显示出优异的味道评分和显著减少的不良反应 (6.5%对32.5%,P<0.05).
结论:
- 与PEG相比,乳酪糖口服液是一种优越的肠道制备剂,提供更好的质量,味道和安全性.
- 它的有效性在正常和高BMI的患者中尤为显著.
- 乳酪糖在未来的结肠镜检查过程中为临床使用提供了一个有希望的替代品.
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