身体脂肪分布模式的曲与特定心脏代谢疾病风险概况的联系
Jennifer Linge1,2, Bertrand Cariou3, Ian J Neeland4
1AMRA Medical AB, Badhusgatan 5, SE-58222 Linköping, Sweden.
The Journal of clinical endocrinology and metabolism
|October 5, 2023
概括
脂肪分布模式,特别是高内脏脂肪组织 (VAT) 和肝脂肪 (LF),与心脏代谢风险增加有关. 脂肪分布的不平衡,特别是高增值税,显著提高2型糖尿病 (T2D) 和心血管疾病 (CVD) 的风险.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 医疗成像医学成像
背景情况:
- 心脏代谢风险受脂肪分布模式的影响.
- 内脏脂肪组织 (VAT),腹部皮下脂肪组织 (aSAT) 和肝脂肪 (LF) 是关键指标.
- 了解它们的相互作用对于风险评估至关重要.
研究的目的:
- 评估增值税,aSAT和LF余额与发生的2型糖尿病 (T2D) 和心血管疾病 (CVD) 之间的关联.
- 根据独立于BMI的脂肪分布模式来评估心脏代谢风险.
主要方法:
- 分析了来自40174名英国生物库参与者的MRI数据,用于VAT,aSAT和LF.
- 脂肪z-score (z-VAT,z-aSAT,z-LF) 的计算以实现BMI的正常化.
- 考克斯回归模型用于在35,138名没有流行疾病的参与者中调查T2D和CVD的关联.
主要成果:
- 高肝脂肪 (z-LF > 0) 和内脏脂肪组织 (z-VAT > 0) 与增加T2D风险显著相关.
- 高增值税 (z-增值税>0) 与心血管疾病风险密切相关.
- 特定的不平衡脂肪分布模式,如高增值税与低LF (z-VAT>0和z-LF<0),显示心血管疾病风险较高.
结论:
- 与BMI相对较高的增值税是T2D和CVD的一致风险因素.
- 高LF与T2D风险特别相关.
- 偏斜的脂肪分布模式,特别是涉及增值税,表明心脏代谢风险增加.
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