乳酸盐通过驱动巨细胞M2极化促进沙门氏菌的细胞内复制和系统性感染
Xinyue Wang1, Bin Yang1, Shuangshuang Ma1,2
1The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, TEDA Institute of Biological Sciences and Biotechnology, Nankai University , Tianjin, China.
Microbiology spectrum
|October 5, 2023
概括
巨菌衍生乳酸通过促进M2极化,促进沙门氏菌生长和全身感染. 这种乳酸诱导的M2极化是沙门氏菌的关键.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 代谢途径 代谢途径
背景情况:
- 沙门氏菌是一种主要的肠病原体,通过巨细胞的存活和复制引起系统性感染.
- 乳酸盐是感染期间丰富的代谢物,可以使巨细胞偏向M2表型.
研究的目的:
- 调查巨菌衍生乳酸在促进沙门氏菌细胞内复制和全身感染中的作用.
- 阐明乳酸盐影响巨细胞两极化和沙门氏菌生长的机制.
主要方法:
- 在巨细胞中利用沙门氏菌感染模型.
- 分析了乳酸生产及其对巨细胞M2极化的影响.
- 研究了沙门氏菌III型分泌系统效应器SteE.E.的参与.
主要成果:
- 巨菌衍生乳酸可显著促进沙门氏菌细胞内复制和全身感染.
- 乳酸盐通过沙门氏菌效应体SteE诱导巨细胞M2极化.
- 乳酸介导的M2极化对于促进沙门氏菌生长至关重要.
结论:
- 巨乳酸是增强沙门氏菌毒性的一个关键因素.
- 乳酸代谢,巨细胞两极分化和沙门氏菌病变之间的相互作用提供了新的治疗点.
- 这项研究揭示了宿主-病原体相互作用中的一种新的代谢界面.
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